Mouse integration with terminal multiplexers
Untested by me. Supposed to work with byobu, an alternative to screen and tmux (and is in fact based on them).
Yes, this is very much possible. You simply need to turn on mouse support in your ~/.byobu/.tmux.conf configuration
set -g mouse-select-pane on
set -g mouse-select-window on
set -g mouse-resize-pane on
set -g mouse-utf8 on
Read more: Link - Can I use mouse click to focus on Byobu splits? - Ask Ubuntu
tmux and mouse mode - Dan Lowe