Restraining mice for half an hour, a situation that replicates the body’s reaction to low-level anxiety, fear or social stress, resulted only in a transient phosphorylation of tau. However, when Rissman simulated chronic stress by repeating the procedure every day for two weeks, the modification lasted long enough to let tau molecules tumble off the cytoskeleton and pile up in insoluble heaps of protein.
My bottom line: no matter how genetically similar or different people are, genetics cannot justify moral action. Although we are now in a time when it is fashionable to use genetics as a kind of self-evident argument for human equality, not very many years ago fashionable opinion found self-evident racial superiority. And given the increasing prevalence of genetic testing of all kinds, the pendulum may well swing back the other way, giving rise to various flavors of "allelism". I think it is better to recognize that moral action doesn't derive from scientific observations.
The plaintiffs, John Henry Browne and Alan Wenokur, are practicing lawyers in Seattle who called the system unfair. They think their ratings, 5.2 and 6.5, respectively, were uncharacteristic of their experience, industry recognition and professional conduct.Från sajten:
Observera att det gäller amerikanska advokater här - inte svenska.
Free ratings and profiles for every lawyer so you can choose the right lawyer * Profiles for every lawyer in the state * Unbiased Avvo Rating (learn more) * Disciplinary sanction history * Ratings and reviews from clients * Avvo 3-Step Guide to Choosing a Lawyer (learn more)
De kartongklädda gipsskivorna som stomme till kaklade väggar är rena drivbänken för farliga mögelsvampar när det kommer in fukt, visar testet.Och då undrar man ju: Vem tusan kom på idén att ha papp (kartong) i byggmaterialen för våtrum??
Kartongklädda gipsskivor bakom kakelväggar kan förvandla det nyrenoverade badrummet till en drivbänk för mögel.
"Socialdemokraterna måste minska sina utgifter. Därför väljer partiledningen att bolagisera och privatisera stora delar av verksamheten..."
"...Riksdagskansliet har minskats från 128 till 90 tjänster. Nu går Mona Sahlin och den övriga s-ledningen vidare med att hårdbanta partihögkvarteret på Sveavägen i Stockholm.
Efter fackliga förhandlingar står det klart att partikansliet minskas från 65 till 39 tjänster. Ett 30-tal anställda försvinner..."
"Socialdemokraterna agerar även på andra sätt strikt företagsmässigt:
Partiet bolagiserar partihuset på Sveavägen 68. I ett nytt dotterbolag till fastighetsbolaget Adolf Fredrik anställs tio personer – dels fastighetsskötare, men även vaktmästare och växeltelefonister. De tar hand om driften av ett helt kontorshotell för hyresgäster inom arbetarrörelsen.
Socialdemokraterna privatiserar samtidigt en rad tjänster. Partiet köper stöd och service på den privata marknaden för löneadministration, ekonomi och it-tjänster."
The ENCODE consortium’s major findings include the discovery that the majority of DNA in the human genome is transcribed into functional molecules, called RNA, and that these transcripts extensively overlap one another. This broad pattern of transcription challenges the long-standing view that the human genome consists of a relatively small set of discrete genes, along with a vast amount of so-called junk DNA that is not biologically active.
The new data indicate the genome contains very little unused sequences and, in fact, is a complex, interwoven network. In this network, genes are just one of many types of DNA sequences that have a functional impact. “Our perspective of transcription and genes may have to evolve,” the researchers state in their Nature paper, noting the network model of the genome “poses some interesting mechanistic questions” that have yet to be answered.
actually if I remember correctly, there are 30,000 known genes which produce about 100,000 proteins [a little more than 3 per gene] which span a much larger amount of DNA that actually codes for proteins. genes have been known to code for multiple proteins since the Human genome project was completed. It has also been known that certain non-coding regions of DNA are not useless but in fact code for things like ribozymes etc. The article also talks about non-coding regions acting as a source for new structures. that is to say that the non-coding regions mutate and are selected for or against over time to form new proteins/enzymes etc.
Ever since the human-genome project was completed, it has puzzled biologists that animals, be they worms, flies or people, all seem to have about the same number of genes for proteins—around 20,000. Yet flies are more complex than worms, and people are more complex than either. Traditional genes are thus not as important as proponents of human nature had suspected nor as proponents of nurture had feared. Instead, the solution to the puzzle seems to lie in the RNA operating system of the cells. This gets bigger with each advance in complexity. And it is noticeably different in a human from that in the brain of a chimpanzee.
Hamas kontrollerar nu hela Gaza och de Fatah-styrkor som inte lyckats lämna området har dödats. Dagens nätbilaga av Jerusalem Post berättar om hur Hamas-milis lett ut Fatah-män som gett upp striden på gatan och sedan avrättat dem. Krav på internationell fredsbevarande närvaro i Gaza har hörts de senaste dagarna. Hamas säger idag att man tänker betrakta en sådan närvaro som ockupation och bekämpa den.
When the neurons are young, Surmeier found they actually use sodium ions to do their work. But as the neurons age, they become more and more dependent on the troublesome calcium and stop using sodium. This calcium dependence – and the stress it causes the neurons --is what makes them more vulnerable to death. What would happen, Surmeier wondered, if he simply blocked the calcium’s route into the adult neuron cells" Would the neurons revert to their youthful behavior and start using sodium again"
However, the picture changed when researchers raised the 'cognitive load' on interviewees by asking them to tell their stories in reverse order. Professor Vrij explained: "Lying takes a lot of mental effort in some situations, and we wanted to test the idea that introducing an extra demand would induce additional cues in liars.
Det blir inte roligare felsägning än så här, av s-oppositionens ledare i Malmö:
http://youtube.com/watch?v=0djLA8bCiT0
(min fetstil)
For almost six decades, U.S. military power has frustrated the ambitions of China's ruling Communist Party to unite Taiwan with the mainland.
Den här bloggen ligger i content management-systemet Plone, och Plone kan bli långsamt om man inte vidtar rätt åtgärder. Den här bloggen ska flyttas till snabbare hårdvara, men i väntan på det så har jag konfigurerat Cache-fu, en uppsättning cachningsstrategier för Plone. Och resultaten är dramatiska. Innan kunde det ta fem sekunder att ladda hemsidan (mätt med Apache-verktyget ab, detta exkluderar bilder, style sheets och javascript). Nu går det på mindre än 0,2 sekunder.
Jag har också trimmat newsfeedsen, så de bör också gå snabbare, vilket kan vara bra eftersom en stor del av min läsekrets läser sajten via dem. Hela blogginläggen finns i feedsen.
Jag lärde mig en del om cachning på vägen också. Cachning ökar komplexiteten på en webbsajt, men de cachningsstrategier som nu är på plats ska uppdatera ordentligt vid ändringar. Allt är lätt när man väl kan det :-)
Surgeons don't do spinal fusions because they're evil and avaricious. They do them because they want to help people; surgery is the way they know how to help people; they are sometimes not terribly good at reading data; and they are, like mutual fund managers and almost everyone else, convinced that even if spinal fusions don't work on average, they can beat the averages. For whatever reason, neither American culture nor the market are providing checks on these bad behaviours--and before you start saying "This is why we need single payer", neither is the government that pays for so many of these treatments.
Scientists at the institute designed the bacterium to have a “minimal genome”—the smallest set of genes any organism can live on.
The results show that the combination of high SCR and high family risk predicted substantial increases in personality change and behavior problems. The researchers observed the children four separate times over the course of six years, making this the first study to show that the interaction of family adversity with a biological characteristic is associated with longitudinally measured change in childhood personality.
Polish and Romanian security officials have confirmed to Europe's human rights watchdog that the two countries hosted secret and illegal CIA prisons, while the watchdog also says that EU member states were aware of CIA kidnappings and rendition flights, UK daily the Guardian has reported.
Researchers at Burnham Institute for Medical Research (“Burnham”) have provided the first evidence that gamma-secretase, an enzyme key to the progression of Alzheimer’s, acts as a tumor suppressor by altering the pathway of epidermal growth factor receptor (EGFR), a potential treatment target for cancer. Expedited to publication online by Proceedings of the National Academy of Sciences, these findings reveal a limitation of targeting gamma-secretase for treatment of Alzheimer’s and potentially other diseases.
Tehran calls Syrian diplomacy haphazard and risky. For some Iranian diplomats, this Syrian behavior will profit Washington rather than Damascus. Furthermore, Iranians are well aware that the US in particular and the West in general are trying to drive a wedge between Damascus and Tehran in order to weaken them both. Because of this, Tehran is not going to yield any regional files to Syria. Tehran feared that in order to avoid the International tribunal in the case of the murder of Rafik Hariri, Syria will turn its back on Iran.